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Timeline

History of antibiotics

1,500BC Pre-antibiotics
400BC Miasma theory
1546 1546: Germ theory
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Pre-antibiotics

Ancient cultures used plants, moulds and soil to treat bacterial infections. Tetracycline – a natural chemical compound later discovered and patented as an oral antibiotic in 1948 – has been found in human skeletal remains in Egypt and the Sudan that are around 1,500 years old. Quisque ut feugiat leo. Praesent feugiat odio vitae mollis fringilla las.

In ancient Greece, Egypt, and China, mouldy bread was pressed onto wounds to prevent infection.

Now scientists know that the active chemicals and metabolites present in early treatments meant that they were occasionally effective. For example, the moulds on bread produced antimicrobial substances.

Miasma theory

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1546: Germ theory

Germ theory states that microorganisms known as pathogens
or “germs” can lead to disease. These organisms are too small
to be seen with the naked eye. They invade human, animal,
and other living hosts and grow or reproduce, causing disease.
A germ can be any type of microorganism, including bacterium,
fungi, or viruses. Basic forms of this theory were proposed by
Italian physician Girolamo Fracastoro in 1546. It is still an
accepted scientific theory.

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